“My husband couldn’t believe it,” said one of our customers on the phone yesterday, “we were on holiday in Thailand, and my husband always gets a heat rash from the sun and the heat. I applied the gel on the skin there, and it was all but gone by the next day. He was skeptical, but I proved him wrong.”

She had phoned me and asked whether the NANO SOMA® Topical Gel might help with this problem he gets every time they go on a beach holiday. I had recommended that they apply the gel to wet skin after a shower, in order to spread it out a little further – as it was all over his back, and partially his chest. She had only taken one bottle of gel in case of insect bites, scratches or cuts.

Our skin is the largest and most visible organ, often mistreated and ignored, or reduced to appearance and aesthetics.

In keeping with the analogy of NANO SOMA conducting our cellular metabolism, and the nuclear receptors being the basic harmony, I would like to highlight 5 key nuclear receptors and their influence on the function of our skin, barrier integrity, a healthy inflammatory response, sebaceous activity, wound healing, and skin aging. These receptors collectively regulate cell differentiation, skin barrier formation, inflammatory responses, wound repair, pigmentation, and sebaceous (the oily bit) gland function:

1. Peroxisome Proliferator-Activated Receptor Gamma (PPARγ)
2. Peroxisome Proliferator-Activated Receptor Beta/Delta (PPARβ/δ)
3. Retinoic Acid Receptor (RAR)
4. Vitamin D Receptor (VDR)
5. Liver X Receptor (LXR)

1. PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)

Major skin functions

• Sebaceous gland development and function
• Producing the oiliness on the skin
• Anti-inflammatory signaling
• Barrier maintenance

When PPARγ is overactive

1. Increased sebaceous activity and oilyness of the skin
2. Excess fat accumulation within skin cells
3. Suppression of protective inflammatory responses, potentially impairing antimicrobial defense

When PPARγ is underactive

1. Dry skin due to reduced oil production
2. Impaired skin barrier with increased water loss through the skin
3. Increased inflammatory skin disorders (eczema-like inflammation)

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2. PPARβ/δ (Peroxisome Proliferator-Activated Receptor Beta/Delta)

Major skin functions

• Wound healing
• Epidermal (outer skin layer) differentiation
• Regulation of inflammation

When PPARβ/δ is overactive

1. Skin thickening
2. Skin hardening
3. Increased risk of psoriasis-like pathology

When PPARβ/δ is underactive

1. Delayed wound healing
2. Reduced skin repair after injury
3. Defective differentiation of the different skin cells

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3. RAR (Retinoic Acid Receptor)

Major skin functions

• Self-replacement of the skin
• Collagen production
• Regulation of pigmentation

When RAR is overactive

1. Excessive skin replacing causing irritation and peeling
2. Increased skin sensitivity and redness
3. Barrier disruption with dryness

When RAR is underactive

1. Chapped and rough skin texture
2. Reduced collagen synthesis leading to accelerated aging
3. Increased black head formation and acne tendency

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4. VDR (Vitamin D Receptor)

Major skin functions

• Skin cell differentiation
• Immune regulation
• Hair follicle cycling
• Barrier homeostasis

When VDR is overactive

1. Excessive suppression of inflammatory responses
2. Reduced skin cell proliferation
3. Potential impairment of normal wound-healing dynamics

When VDR is underactive

1. Defective epidermal differentiation
2. Increased susceptibility to inflammatory skin disease
3. Hair follicle dysfunction and hair loss

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5. LXT (Liver X Receptor)

Major skin functions

• Cholesterol metabolism
• Epidermal lipid production
• Barrier repair
• Regulation of inflammation

When LXR is overactive

1. Excessive lipid accumulation in epidermal cells
2. Increased sebaceous production
3. Altered epidermal architecture from excessive lipid signaling

When LXR is underactive

1. Reduced cholesterol and ceramide synthesis
2. Impaired barrier repair after injury
3. Increased skin dryness and inflammation

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NANO SOMA®: Support the Orchestra of Your Body

This is just a condensed and simplified version of all that the NANO SOMA® Liquid will help your body conduct in its maximum harmony, so that your body can maintain the harmony of your skin from the inside-out.*

However, you can also support your body to achieve this harmony from the outside-in.

So, this summer when you are showing more skin and exposing it to the sun, remember the importance of skin health. Consider using the NANO SOMA® Skin Cream to maintain your skin’s function and integrity.* And in the case of cuts, burns and other incidents, like the husband of our customer mentioned above experienced, remember to pack some NANO SOMA® Topical Gel in your beach or pool bag as well.

Your skin likes sun, dislikes sunburn, and loves what NANO SOMA can do for it.

Are You Ready To See What It Can Do For You?

Tap the button below and discover how you can!

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*These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose or prescribe for any medical condition, nor to prevent, treat, mitigate, or cure such condition(s). If you have any illness or medical condition, consult your healthcare provider.