Research Central: Research Shows Metadichol® Activates All 49 Human Nuclear Receptors

Summary of the peer-reviewed article “Metadichol®: A Nano Lipid Emulsion that Expresses All 49 Nuclear Receptors in Stem and Somatic Cells” by Dr. Palayakotai R. Raghavan, published in the Archives of Clinical and Biomedical Research, October 2023. Read the full article here.

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A recent study by Dr. Palayakotai R. Raghavan, creator of NANO SOMA®, offers groundbreaking insight into Metadichol®, the key ingredient in the MagicDichol® Family of Products.

This natural nanoemulsion, made from long-chain lipid alcohols, was found to activate all 49 known human nuclear receptors in both stem cells (the body’s raw materials, which can develop into many different cell types) and fibroblast cells (cells that build and maintain connective tissue).

The Research at a Glance

Using quantitative real-time PCR and Western blotting, researchers treated human umbilical cord stem cells and fibroblasts with various concentrations of Metadichol. The results were clear and consistent: every nuclear receptor responded, showing a measurable increase in expression in a dose-dependent manner.

This is the first time a natural compound has been shown to activate the full nuclear receptor superfamily—something that could have wide-reaching implications for how the body regulates gene expression and supports health.

Why It Matters

Nuclear receptors are proteins inside cells that act as genetic switches. They respond to signals—such as hormones or nutrients—by turning genes on or off. These switches help regulate metabolism, immunity, cell repair, and more. While some, like the vitamin D receptor, are well understood, many others—called orphan receptors—have remained inactive due to the lack of a known natural activator.

Metadichol seems to work like a universal modulator, naturally activating these important cellular systems. Instead of forcing change, it helps the body fine-tune its own processes—working with, not against, its built-in intelligence.

What This Means for You

This study sheds light on how the MagicDichol® Family of Products, including the NANO SOMA® Liquid, Topical Gel, and Skin Cream, support the body in a truly foundational way.

Activating all 49 nuclear receptors—something never documented before—means engaging the body’s full internal communication network.

Rather than addressing surface-level concerns, these products work with your body’s core signaling systems, gently prompting them to restore, recalibrate, and function as they were designed to.*

To explore further how Metadichol® works and what emerging science means for your well-being, check out our Research Central blog series. It’s designed to break down complex studies into clear, easy-to-understand insights—so you can stay informed, empowered, and supported in your health journey.

 

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*These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose or prescribe for any medical condition, nor to prevent, treat, mitigate, or cure such condition(s). If you have any illness or medical condition, consult your healthcare provider.